Agmatine Sulfate supplement can reduce your tolerance to opiate and opiate like pain medicine (Kratom).
I
recently found Kratom was not working effectively as my tolerance
required doses to increase over time from 8g to 15g per dose. When my
third and or fourth dose of Kratom at 15g was not working anymore, I
switched to Oxycontin and Ibuprofren for 7 days. On the 8th day it was
time to switch back to Kratom.
I started the day with Agmatine
Sulfate 1760mg on an empty stomach in the morning. Ceasing all Oxycontin
intake I resumed Kratom therapy at just 8g per dose one half hour
later. I has been 2 days and the Kratom is working again at this lowered
dose. I take at least one additional 890mg dose of Agmatine later that
day, on the second day (and every second day) this becomes two doses for
an additional 1760mg.
I am pleasantly surprised. More related information and references below for those interested:
Effects of Agmatine on tolerance to and substance dependence on morphine in mice.
/www.ncbi.nlm.nih.gov/pubmed/10452098
Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury
/www.ncbi.nlm.nih.gov/pmc/articles/PMC27068/
How to take Agmatine
www.supplementcritic.com/agmatine/
Agmatine is a metabolite of L-Arginine, but acts very differently. Do not take with L-Arganine.
Also
dont take Agmatine with Yohimbe since Yohimbe deactivates the a2
adreneric receptors, whereas Agmatine activates/binds to that same
receptor.
It shows promise for alleviating neuropathic pain and
drug addiction but without opiate use has been known to increase
perceived pain. Agmatine supplementation can also protect from strokes
and benefit cognitive health.
/examine.com/supplements/agmatine/
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